Huang, Jian; Kong, Han-Han; Li, Si-Jia; Zhang, Rui-Jin; Qian, Hao-Dong; Li, Dan-Ran; He, Jin-Yu; Zheng, Yi-Nuo; Xu, Hao published the artcile< Asymmetric copper-catalyzed propargylic amination with amine hydrochloride salts>, Category: esters-buliding-blocks, the main research area is propargylic amination amine hydrochloride salt.
The highly enantioselective copper-catalyzed propargylic amination of propargylic esters with amine hydrochloride salts has been realized for the first time using copper salts with chiral N,N,P-ligands. This method features a broad substrate scope and wide functional group tolerance, generating propargylic amines in good to excellent yields with high enantioselectivities (up to 99% ee). The utility of the approach was demonstrated by late-stage functionalization of marketed pharmaceuticals.
Chemical Communications (Cambridge, United Kingdom) published new progress about Amination. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics