Douglas, Alastair J.; Walker, Brian; Johnston, Colin F.; Murphy, Richard F. published the artcile< Visualization of the gastrin receptor within rat mucosa using a biotinylated gastrin antagonist>, Application In Synthesis of 112-63-0, the main research area is gastrin receptor mucosa visualization biotinylated antagonist.
The peptide Boc-L-Trp-L-Leu-β-Ala is a potent and specific antagonist of pentagastrin-stimulated acid secretion in both the rat and the dog. Using conventional solution phase methodol., the analog biotinyl-L-Trp-L-Leu-β-Ala was prepared in reasonable yield and purity and applied to cryostat sections of rat intestinal and other tissues. The sections were exposed to 5-10 μg of peptide and the bound analog was visualized using streptavidin-fluorescein. The binding of the analog was demonstrated in sections from fundus, duodenum, ileum, colon, and lung. However, the analog failed to bind to tissue from the pancreas, heart, kidney, or liver. The binding of the probe was greatly reduced or completely inhibited by preincubation with Boc-L-Trp-L-Leu-β-Ala, pentagastrin, or gastrin 1-17. The distribution of the cells recognized by the probe was consistent with the distribution of histamine-containing enterochromaffin-like cells. The results of this study may have some bearing on current theories of the mechanism of gastrin-stimulated acid release.
International Journal of Peptide & Protein Research published new progress about Duodenum. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
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