In 2012,Degorce, Sebastien; Delouvrie, Benedicte; Davey, Paul R. J.; Didelot, Myriam; Germain, Herve; Harris, Craig S.; Brempt, Christine Lambert-van der; Lebraud, Honorine; Ouvry, Gilles published 《Facile, diversity-orientated one-pot synthesis of ethyl 1,5-disubstituted-1H-1,2,4-triazole-3-carboxylates》.Tetrahedron Letters published the findings.Name: Ethyl 2-amino-2-thioxoacetate The information in the text is summarized as follows:
Access to the 1,5-disubstituted-1H-1,2,4-triazole-3-carboxamide motif is quite laborious and requires forcing conditions to effect the cyclocondensation step. Herein, we report an efficient and mild one-pot protocol to access the corresponding triazolecarboxylate substructure, e.g., I, in good chem. yields with high regiocontrol. In the experimental materials used by the author, we found Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Name: Ethyl 2-amino-2-thioxoacetate)
Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Name: Ethyl 2-amino-2-thioxoacetate
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