《Organocatalytic Hantzsch Type Reaction Using Aryl Hydrazines, Propiolic Acid Esters and Enals: Enantioselective Synthesis of Paroxetine》 was written by Chen, Lu; Zhang, Zhi; Zu, Liansuo. Safety of Ethyl propiolateThis research focused onunsubstituted hydropyridine preparation enantioselective diastereoselective; aryl hydrazine propiolic acid ester enal Hantzsch reaction organocatalyst. The article conveys some information:
Aryl hydrazines, propiolic acid esters and enals served as a viable substrate combination for an organocatalytic enantioselective Hantzsch type reaction. The method converted readily available starting materials into important chiral heterocycles with good to excellent yields and enantioselectivities, and addressed the longstanding scope limitation of the classic Hantzsch reaction in the asym. synthesis of 2,6-unsubstituted hydropyridines. The synthetic utility was demonstrated by the concise enantioselective synthesis of paroxetine. In addition to this study using Ethyl propiolate, there are many other studies that have used Ethyl propiolate(cas: 623-47-2Safety of Ethyl propiolate) was used in this study.
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Safety of Ethyl propiolate
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