Application of 403-33-8In 2020 ,《Ni-catalyzed direct alcoholysis of N-acylpyrrole-type tertiary amides under mild conditions》 was published in Science China: Chemistry. The article was written by Chen, Hang; Chen, Dong-Huang; Huang, Pei-Qiang. The article contains the following contents:
Reported that by employing Ni(COD)2/2,2′-bipyridine (5 mol%) catalytic system, the direct, catalytic alcoholysis of N-acylpyrrole-type aromatic and aliphatic amides with both primary and secondary alcs. can be achieved efficiently under very mild conditions (rt, 1 h) even at gram scale. By increasing the catalyst loading to 10 mol%, prolonging reaction time (18 h), and/or elevating reaction temperature to 50°C/80°C, the reaction could be extended to both complex and hindered N-acylpyrroles as well as to N-acylpyrazoles, N-acylindoles, and to other (functionalized) primary and secondary alcs. In all cases, only 1.5 equivalent of alc. were used. The value of the method has been demonstrated by the racemization-free, catalytic alcoholysis of chiral amides yielded from other asym. methodologies. After reading the article, we found that the author used Methyl 4-fluorobenzoate(cas: 403-33-8Application of 403-33-8)
Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Application of 403-33-8
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