Chang, Wenxu; Li, Zongyang; Yuan, Chenhui; Liu, Xinying; Feng, Jiyao; Pang, Sen; Duan, Liusheng; Zhang, Zhenhua published an article in 2022. The article was titled 《Synthesis of Highly Substituted 2-Aminopyridines from Vinyl Azides, Isonitriles, and Ketones》, and you may find the article in Chemistry – An Asian Journal.Application of 4949-44-4 The information in the text is summarized as follows:
Authors developed a facile, efficient method for synthesizing highly substituted 2-aminopyridines I (R1 = Ph, 2-MeC6H4, 4-ClC6H4, etc.; R2 = t-Bu, c-hexyl, Bn, etc.; R3 = Me, i-Pr, 4-O2NC6H4, etc.; R4 = CN, COMe, COOEt, etc.) from unstable vinyl carbodiimides generated in situ in a one-pot transformation. A series of novel highly substituted 3-functionalized 2-aminopyridines were produced in good yields. Reaction mechanism studies, which included control experiments and d.-functional theory (DFT) calculations, demonstrated that Rh and potassium carbonate played key roles in the cyclization step. After reading the article, we found that the author used Ethyl 3-oxopentanoate(cas: 4949-44-4Application of 4949-44-4)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Application of 4949-44-4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics