Canale, Vittorio; Frisi, Valeria; Bantreil, Xavier; Lamaty, Frederic; Zajdel, Pawel published the artcile< Sustainable Synthesis of a Potent and Selective 5-HT7 Receptor Antagonist Using a Mechanochemical Approach>, Quality Control of 287114-25-4, the main research area is benzenesulfonamide PZ1361 synthesis antidepressant serotonin 5HT7 receptor.
A mechanochem. procedure was developed to obtain PZ-1361, a potent and selective 5-HT7 receptor antagonist, with antidepressant properties in rodents. The elaborated protocol offered several advantages over classical batch synthesis, including improvement of the overall yield (from 34% to 64%), reduction of reaction time (from 60 to 5.5 h), limitation of the use of toxic solvents, and the formation of byproducts. This approach represents a rare example of the synthesis of biol. active compounds exclusively performed using mechanochem. reactions.
Journal of Organic Chemistry published new progress about 5-HT7 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 287114-25-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H22N2O2, Quality Control of 287114-25-4.
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