Campbell, Shirley E.; Comer, Murray C.; Derbyshire, Paul A.; Despinoy, Xavier L. M.; McNab, Hamish; Morrison, Roderick; Sommerville, Craig C.; Thornley, Craig published the artcile< Synthesis of pyrrolizin-3-ones by flash vacuum pyrolysis of pyrrol-2-ylmethylidene Meldrum's acid derivatives and 3-(pyrrol-2-yl)propenoic esters>, COA of Formula: C8H9NO3, the main research area is pyrrolizinone preparation flash vacuum pyrolysis; flash vacuum pyrolysis pyrrolylmethylidene Meldrums acid; pyrrolylpropenoic ester flash vacuum pyrolysis; pyrolysis flash vacuum Meldrums acid pyrrolylpropenoate.
Monosubstituted pyrrolizin-3-ones, e.g., I (R1 = Me, H, R5 = CO2Et, Ph, H, R6 = Ph, H, R7 = Me, OMe, CO2Me, Ph, H) with substituents at the 1-, 5-, 6- or 7-positions are prepared in excellent yield by flash vacuum pyrolysis (FVP) of appropriate Meldrum’s acid derivatives The mechanism involves formation of the pyrrol-2-ylmethylideneketene , which can also be generated thermally from 3-(pyrrol-2-yl)propenoate esters. This alternative route has been used to make a range of 2-substituted pyrrolizin-3-ones, again in excellent yield. The 3-oxo-3H-pyrrolizine-2-carboxylic acid could not be made in this way owing to facile decarboxylation to pyrrolizinone I, and extension to the formation of the azaazulenone II was again unsuccessful.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about 7126-50-3. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, COA of Formula: C8H9NO3.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics