《Synthesis, characterization and antioxidant activity of chitosan Schiff base derivatives bearing (-)-gossypol》 was published in Carbohydrate Polymers in 2020. These research results belong to Beyazit, Neslihan; Cakran, Halide Sinem; Cabir, Ali; Akiscan, Yasar; Demetgul, Cahit. Synthetic Route of C12H15ClN2O2 The article mentions the following:
In this work, two new chitosan-Schiff base derivatives (HCS-GSP and LCS-GSP) were synthesized by the condensation reaction of high mol. weight chitosan (HCS) and low mol. weight chitosan (LCS) with (-)-gossypol (GSP), resp. For this purpose, racemic gossypol was isolated from cotton seeds and it was further enantiomerically purified by diastereomeric resolution technique using L-tryptophan Me ester hydrochloride. Then, chitosan polymers were derivatized with (-)-gossypol by the condensation reaction. The isolated and synthesized compounds were characterized by phys. measurements and spectroscopic methods (elemental anal. C,H,N, Uv-vis, FT-IR, 1H&13C NMR and TG/DTG/DTA). The antioxidant activity of high mol. weight chitosan (HCS), low mol. weight chitosan (LCS) and their gossypol derivatives was evaluated as radical scavengers against 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH). The results showed that both of the chitosan-gossypol derivatives (HCS-GSP and LCS-GSP) had a better ability to scavenging DPPH radical (IC50, 12 μg/mL and 16 μg/mL, resp.) than its unmodified chitosan. In the part of experimental materials, we found many familiar compounds, such as H-Trp-OMe.HCl(cas: 7524-52-9Synthetic Route of C12H15ClN2O2)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Synthetic Route of C12H15ClN2O2
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