Abdelkawy, Mahmoud A.; Davin, Christopher; Aly, El-Saied A.; El-Badawi, Mahmoud A.; Itsuno, Shinichi published their research in ChemistrySelect in 2021. The article was titled 《Chiral Polyureas Derived Cinchona Alkaloids: Highly Efficient Bifunctional Organocatalysts for the Asymmetric Michael Addition Reaction》.Synthetic Route of C7H12O3 The article contains the following contents:
Repetitive Mizoroki-Heck (MH) coupling polymerization was used to create novel chiral polyureas with cinchona alkaloids in the main chain. Apart from two-component polycondensation of cinchona urea dimers with diiodobenzene via MH reaction conditions, some chiral polyureas were easily polymerized under self polycondensation to yield the chiral polymers. The asym. Michael addition reaction was successfully carried out using chiral polymers derived cinchona urea. Interestingly, phenolic-based chiral polymers served as heterogeneous catalysts for the enantioselective Michael reaction, with high catalytic activity and excellent enantioselectivities (up to 99% ee). These polymeric catalysts were also stable, and they could be recycled and reused. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Synthetic Route of C7H12O3)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Synthetic Route of C7H12O3
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