The author of 《Design, synthesis and antimycobacterial activity of less lipophilic Q203 derivatives containing alkaline fused ring moieties》 were Wang, Apeng; Wang, Hongjian; Geng, Yunhe; Fu, Lei; Gu, Jian; Wang, Bin; Lv, Kai; Liu, Mingliang; Tao, Zeyu; Ma, Chao; Lu, Yu. And the article was published in Bioorganic & Medicinal Chemistry in 2019. Category: esters-buliding-blocks The author mentioned the following in the article:
We report herein the design and synthesis of a series of less lipophilic Q203 derivatives containing an alk. fused ring moiety. Most of them show considerable potency against MTB H37Rv strain (MIC < 0.25 μM). Nine compounds (13, 15, 19, 21, 23, 25, 29, 35, 36) have the same excellent activity against both drug-sensitive and -resistant strains (MIC < 0.035 μM) as Q203 and PBTZ169. Especially, compound 29 also displays acceptable safety, greater absorption in plasma and aqueous solubility than Q203, suggesting its promising potential to be lead compound for future antitubercular drug discovery. In the experimental materials used by the author, we found Ethyl 3-oxopentanoate(cas: 4949-44-4Category: esters-buliding-blocks)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics