COA of Formula: C4H5ClO3In 2019 ,《Design, synthesis and biological activities of new pyrazole derivatives possessing both coxib and combretastatins pharmacophores》 appeared in Chemistry & Biodiversity. The author of the article were Thi, Thuy Hang Nguyen; Thi, Yen Tran; Nguyen, Le Anh; Vo, Ngoc Binh; Ngo, Quoc Anh. The article conveys some information:
In our efforts to discover novel multi-target agents having better antitumor activities than celecoxib, 21 new aryl-substituted pyrazole derivatives possessing cis-diphenylethylene scaffold were mostly synthesized by a one-pot approach to Et 1,4,5-triaryl-1H-pyrazole-3-carboxylates via an improved Claisen condensation – Knorr reaction sequence. The cytotoxic effects of these compounds against three human cancer cell lines HT-29, Hep-G2, MCF-7 as well as their inhibition of NO production were studied. Results showed that incorporation of the important pharmacophoric groups of two original mols. celecoxib and combretastatin A-4 in a single mol. plays an important role in determining a better biol. activities of the new coxib-hybrided compounds In the experimental materials used by the author, we found Ethyl oxalyl monochloride(cas: 4755-77-5COA of Formula: C4H5ClO3)
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.COA of Formula: C4H5ClO3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics