In 2017,Shintre, Suhas A.; Ramjugernath, Deresh; Singh, Parvesh; Mocktar, Chunderika; Koorbanally, Neil A. published 《Microwave synthesis, biological evaluation and docking studies of 2-substituted methyl 1-(4-fluorophenyl)-1H-benzimidazole-5-carboxylates》.Medicinal Chemistry Research published the findings.COA of Formula: C8H6FNO4 The information in the text is summarized as follows:
A library of 22 novel 2-substituted fluorinated benzimidazoles (5a-v) was synthesized under microwave conditions in yields of between 85-96% and tested for their antimicrobial and antioxidant activity. Two trioxygenated derivatives 5p and 5r had min. bactericidal concentration values ranging between 14.5-115.7 μM (5p) and 25.6-74.3 μM (5r) against S. aureus, E. coli, P. aeruginosa and K. pneumoniae. The benzimidazole 5e with a CF3 substituent had the best antifungal activity at 94.3 μM against C. albicans. Compounds 5p and 5r also showed good antioxidant activities of 386.6 and 306.7 μM resp., comparable to that of ascorbic acid. Docking studies of 5h and 5r into the active site of topoisomerase II DNA-gyrase indicated that interaction with the Mn2+ ion in the active site of the enzyme was crucial for antibacterial activity. The experimental process involved the reaction of Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9COA of Formula: C8H6FNO4)
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.COA of Formula: C8H6FNO4
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Ester – an overview | ScienceDirect Topics