《Synthesis and Antimicrobial Activity of Burkholderia-Related 4-Hydroxy-3-methyl-2-alkenylquinolines (HMAQs) and Their N-Oxide Counterparts》 was published in Journal of Natural Products in 2020. These research results belong to Piochon, Marianne; Coulon, Pauline M. L.; Caulet, Armand; Groleau, Marie-Christine; Deziel, Eric; Gauthier, Charles. Recommanded Product: Ethyl 3-oxopentanoate The article mentions the following:
The synthesis of a series of six 4-hydroxy-3-methyl-2-alkenylquinolines (HMAQs)/4-hydroxy-3-methyl-2-alkenylquinoline N-oxides (HMAQNOs) featuring a trans-Δ2 double bond at the C2-alkyl chain was reported. The quinolone scaffold was obtained via the Conrad-Limpach approach, while the (E)-2-alkenyl chain was inserted through Suzuki-Miyaura cross-coupling under microwave radiation without noticeable isomerization according to the optimized conditions. Subsequent oxidation of enolate-protected HMAQs cleanly led to the formation of HMAQNOs following cleavage of the Et carbonate group. Synthetic HMAQs/HMAQNOs were evaluated in vitro for their antimicrobial activity against different Gram-neg. and Gram-pos. bacteria as well as against molds and yeasts. The biol. results support and extend the potential of HMAQs/HMAQNOs as antimicrobials, especially against Gram-pos. bacteria. The involvement of HMAQs in the autoregulation of the Hmq system in Burkholderia ambifaria was confirmed. In the experimental materials used by the author, we found Ethyl 3-oxopentanoate(cas: 4949-44-4Recommanded Product: Ethyl 3-oxopentanoate)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: Ethyl 3-oxopentanoate
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