《Triaryl Benzimidazoles as a New Class of Antibacterial Agents against Resistant Pathogenic Microorganisms》 was written by Picconi, Pietro; Hind, Charlotte; Jamshidi, Shirin; Nahar, Kazi; Clifford, Melanie; Wand, Matthew E.; Sutton, J. Mark; Rahman, Khondaker Miraz. SDS of cas: 329-59-9This research focused ontriaryl benzimidazole preparation antibacterial activity pathogenic Microorganisms; DNA minor groove binder triaryl benzimidazole preparation. The article conveys some information:
A new class of nontoxic triaryl benzimidazole compounds, derived from existing classes of DNA minor groove binders, were designed, synthesized, and evaluated for their antibacterial activity against multidrug resistant (MDR) Gram-pos. and Gram-neg. species. Mol. modeling experiments suggest that the newly synthesized class cannot be accommodated within the minor groove of DNA due to a change in the shape of the mols. Compounds 2-methyl-1-(5-{3-[(2-methyl-3H-benzoimidazole-5-carbonyl)amino]-phenyl}-pyridin-2-yl)-1H-benzoimidazole-5-carboxylic acid (2-Dimethylaminoethyl)amide (8), 2-methyl-1-(5-{3-[(2-methyl-3H-benzoimidazole-5-carbonyl)amino]-phenyl}-pyridin-2-yl)-1H-benzoimidazole-5-carboxylic acid(3-dimethylaminopropyl)amide (13), and N-(4-(dimethylamino)butyl)-2-methyl-1-(5-(3-(2-methyl-1H-benzo[d]imidazole-6-carboxamido)phenyl)pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamide (14) were the most active of the series, with MICs in the range of 0.5-4 μg/mL against the MDR Staphylococci and Enterococci species. Compound 13 showed moderate activity against the MDR Gram-neg. strains, with MICs in the range of 16-32 μg/mL. Active compounds showed a bactericidal mode of action, and a mechanistic study suggested the inhibition of bacterial gyrase as the mechanism of action (MOA) of this chem. class. The MOA was further supported by the mol. modeling study. In addition to this study using Methyl 4-fluoro-3-nitrobenzoate, there are many other studies that have used Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9SDS of cas: 329-59-9) was used in this study.
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.SDS of cas: 329-59-9
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