In 2019,ACS Medicinal Chemistry Letters included an article by Peng, Lijie; Zhang, Zhensheng; Lei, Chong; Li, Shan; Zhang, Zhang; Ren, Xiaomei; Chang, Yu; Zhang, Yan; Xu, Yong; Ding, Ke. Recommanded Product: 51644-96-3. The article was titled 《Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation》. The information in the text is summarized as follows:
A series of (E)-3-(4-((2,4-bis(trifluoromethyl)benzyl)oxy)-3-methoxyphenyl)-2-cyanoacrylamide derivatives were designed and synthesized as new estrogen-related receptor α (ERRα) degraders based on the proteolysis targeting chimera (PROTAC) concept. One of the representative compounds I is capable of specifically degrading ERRα protein by >80% at a relatively low concentration of 30 nM, becoming one of the most potent and selective ERRα degraders to date. Compound I could be utilized as a new powerful research tool for further biol. investigation of ERRα. The results came from multiple reactions, including the reaction of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Recommanded Product: 51644-96-3)
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Recommanded Product: 51644-96-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics