Pacifico, Roberta; Destro, Dario; Gillick-Healy, Malachi W.; Kelly, Brian G.; Adamo, Mauro F. A. published an article in 2021. The article was titled 《Preparation of acidic 5-hydroxy-1,2,3-triazoles via cycloaddition of aryl azides with β-ketoesters》, and you may find the article in Journal of Organic Chemistry.Product Details of 609-14-3 The information in the text is summarized as follows:
A series of 1,2,3-triazoles I (R = H, Me, benzyl; Ar = 3-pyridyl, Ph, 1-naphthyl, etc.) or II (R1 = 2-pyridyl, 3-pyridyl, 4-pyridyl) via cycloaddition reation of β-ketoesters EtOC(O)CH(R)C(O)Me and azides ArN3 and R1N3 in high yields were reported. The reactions employing 2-unsubstituted β-ketoesters EtOC(O)CH2C(O)Me were found to provide 5-Me 1,2,3-triazoles II; whereas 2-alkyl-substituted β-ketoesters provided 5-hydroxy 1,2,3-triazoles I (shown to be relatively acidic) in high yields and as single regioisomers. Several novel compounds were reported and characterized. The synthetic utility of the protocol has been exemplified by the preparation of long-chain 5-hydroxy 1,2,3-triazoles III (R2 = Me, Et; n = 1, 2, 3) with a potentially bioisosteric relationship to hydroxamic acids. In the part of experimental materials, we found many familiar compounds, such as Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Product Details of 609-14-3)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Product Details of 609-14-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics