Owa, Takashi published the artcile< Chemistry and biology of a series of antitumor sulfonamides: exploiting transcriptomic and quantitative proteomic analyses for exploring drug gable chemical space>, Electric Literature of 112-63-0, the main research area is cancer antitumor sulfonamide derivative SAR preparation.
Sulfolnamide-focused compound libraries have been synthesized in our laboratories for biol. evaluation using antitumor phenotypic screens such as cancer cell proliferation assay, flow cytometric cell cycle anal., and rat aorta tube formation assay. Among thousands of sulfonamide compounds evaluated, E7010 (a microtubule depolymerizing agent), E7070 (a G1 phase cell cycle inhibitor), and E7820 (an antiangiogenesis agent) have progressed to clin. trials, thereby demonstrating some objective responses in cancer patients so far. The sequential discovery of these drug candidates allowed us to carry out a research approach of forward chem. genetics, in which phenotypically bioactive compounds are selected from a large collection of small mols. and then utilized for understanding the functions of their protein partners and relevant biol. pathways via target identification. This paper describes our attempt using oligonucleotide microarray and quant. proteomic analyses not only for identifying drug targets and downstream pathways applicable to biomarkers but also for exploring drug gable chem. space in medicinal chem. research.
Yuki Gosei Kagaku Kyokaishi published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics