The author of 《Biomimetic Enantioselective Total Synthesis of (-)-Robustanoids A and B and Analogues》 were Liu, Zhan-Jiang; Huang, Pei-Qiang. And the article was published in Journal of Organic Chemistry in 2019. Safety of H-Trp-OMe.HCl The author mentioned the following in the article:
We report a step-economical, enantioselective total synthesis of (-)-robustanoid B, I (R = MeO), and (-)-robustanoid A, I (R = OH), and four novel natural product-like compounds Our strategy relied on our biosynthetic hypothesis and on a novel complexity generation methodol., namely, the one-pot hydroxylative double cyclization reaction. The latter consists of a modified 3,3-dimethyldioxirane-triggered epoxidation-epoxide-ring-opening cyclization reaction cascade and Trost’s regioselectivity umpolung methodol. (“”anti-Michael addition””). In the experiment, the researchers used many compounds, for example, H-Trp-OMe.HCl(cas: 7524-52-9Safety of H-Trp-OMe.HCl)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Safety of H-Trp-OMe.HCl
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics