Kuo, Ting-Chun’s team published research in Journal of Medicinal Chemistry in 2016 | CAS: 51644-96-3

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Name: tert-Butyl (5-aminopentyl)carbamate

Name: tert-Butyl (5-aminopentyl)carbamateIn 2016 ,《Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin》 appeared in Journal of Medicinal Chemistry. The author of the article were Kuo, Ting-Chun; Li, Ling-Wei; Pan, Szu-Hua; Fang, Jim-Min; Liu, Jyung-Hurng; Cheng, Ting-Jen; Wang, Chia-Jen; Hung, Pei-Fang; Chen, Hsuan-Yu; Hong, Tse-Ming; Hsu, Yuan-Ling; Wong, Chi-Huey; Yang, Pan-Chyr. The article conveys some information:

Microtubule targeting agents (MTAs) constitute a class of drugs for cancer treatment. Despite many MTAs have been proven to significantly improve the treatment outcomes of various malignancies, resistance has usually occurred. By selection from a 2-million entry chem. library based on the efficacy and safety, the authors identified purine-type compounds that were active against lung small cell lung cancer (NSCLC). The purine compound I (GRC0321) was an MTA with good effects against NSCLC. Lung cancer cells H1975 treated with I could induce microtubule fragmentation, leading to G2/M cell cycle arrest and intrinsic apoptosis. Compound I directly targeted katanin and regulated the severing activity of katanin, which cut the cellular microtubules into short pieces and activated c-Jun N-terminal kinases (JNK). The microtubule fragmenting effect of I is a unique mechanism in MTAs. It might overcome the resistance problems that most of the MTAs have faced. In the experimental materials used by the author, we found tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Name: tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Name: tert-Butyl (5-aminopentyl)carbamate

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