In 2016,Hu, Fangdong; Liu, Huanhuan; Jia, Jiong; Ma, Chen published 《Transition-metal-free synthesis of indole-fused dibenzo[b,f][1,4]oxazepines via Smiles rearrangement》.Organic & Biomolecular Chemistry published the findings.Product Details of 329-59-9 The information in the text is summarized as follows:
A one-pot transition-metal-free approach for the synthesis of indole-fused dibenzo[b,f][1,4]oxazepines, e.g., I from 2-(1H-indol-2-yl)phenol and 1,2-dihalobenzenes or 2-halonitroarenes has been developed. The proposed mechanism for this transformation features a Smiles rearrangement favored over a direct intramol. nucleophilic cyclization, which affords the corresponding products in different regioselectivities. This reaction also features simple reaction conditions and wide functional group tolerance. In the experimental materials used by the author, we found Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Product Details of 329-59-9)
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Product Details of 329-59-9Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.
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