《Direct synthesis of 2,3,5-trisubstituted pyrroles via copper-mediated one-pot multicomponent reaction》 was written by He, Jian-Ping; Zhan, Zhen-Zhen; Luo, Nan; Zhang, Ming-Ming; Huang, Guo-Sheng. Formula: C8H7FO2This research focused ontrisubstituted pyrrole preparation; dicarbonyl compound acrylate one pot multicomponent condensation copper catalyst. The article conveys some information:
A copper-mediated one-pot synthesis of 2,3,5-trisubstituted pyrroles from 1,3-dicarbonyl compounds and acrylates using ammonium acetate as a nitrogen source has been developed. The reaction achieves C-C and C-N bond formation and provides an efficient approach to access highly functionalized pyrroles without further raw material preparation This method is operationally simple, compatible with a wide range of functional groups, and provides the target products in moderate to good yields. The experimental process involved the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Formula: C8H7FO2)
Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Formula: C8H7FO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics