Gilpin, Anna; Zeng, Yuze; Hoque, Jiaul; Ryu, Ji Hyun; Yang, Yong; Zauscher, Stefan; Eward, William; Varghese, Shyni published an article in 2021. The article was titled 《Self-Healing of Hyaluronic Acid to Improve In Vivo Retention and Function》, and you may find the article in Advanced Healthcare Materials.Electric Literature of C11H24N2O2 The information in the text is summarized as follows:
Convergent advances in the field of soft matter, macromol. chem., and engineering have led to the development of biomaterials that possess autonomous, adaptive, and self-healing characteristics similar to living systems. These rationally designed biomaterials can surpass the capabilities of their parent material. Herein, the modification of hyaluronic acid (HA) to exhibit self-healing properties is described, and its phys. and biol. function both in vitro and in vivo is studied. The in vitro findings showed that self-healing HA designed to undergo self-repair improves lubrication, enhances free radical scavenging, and attenuates enzymic degradation compared to unmodified HA. Longitudinal imaging following intraarticular injection of self-healing HA shows improved in vivo retention despite its low mol. weight Concomitant with these functions, intraarticular injection of self-healing HA mitigates anterior cruciate ligament injury-mediated cartilage degeneration in rodents. This proof-of-concept study shows how incorporation of functional properties such as self-healing can be used to surpass the existing capabilities of biolubricants. In the experiment, the researchers used many compounds, for example, N-Boc-1,6-Diaminohexane(cas: 51857-17-1Electric Literature of C11H24N2O2)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsElectric Literature of C11H24N2O2
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