Safety of tert-Butyl (5-aminopentyl)carbamateIn 2021 ,《New Pyrimidine and Pyridine Derivatives as Multitarget Cholinesterase Inhibitors: Design, Synthesis, and In Vitro and In Cellulo Evaluation》 appeared in ACS Chemical Neuroscience. The author of the article were Bortolami, Martina; Pandolfi, Fabiana; Tudino, Valeria; Messore, Antonella; Madia, Valentina Noemi; De Vita, Daniela; Di Santo, Roberto; Costi, Roberta; Romeo, Isabella; Alcaro, Stefano; Colone, Marisa; Stringaro, Annarita; Espargaro, Alba; Sabate, Raimon; Scipione, Luigi. The article conveys some information:
A new series of pyrimidine and pyridine diamines was designed as dual binding site inhibitors of cholinesterases (ChEs), characterized by two small aromatic moieties separated by a diaminoalkyl flexible linker. Many compounds are mixed or uncompetitive acetylcholinesterase (AChE) and/or butyrylcholinesterase (BChE) nanomolar inhibitors, with compound 9 being the most active on Electrophorus electricus AChE (EeAChE) (Ki = 0.312μM) and compound 22 on equine BChE (eqBChE) (Ki = 0.099μM). Mol. docking and mol. dynamic studies confirmed the interaction mode of our compounds with the enzymic active site. UV-vis spectroscopic studies showed that these compounds can form complexes with Cu2+ and Fe3+ and that compounds I, II, and III have antioxidant properties. Interestingly, some compounds were also able to reduce Aβ42 and tau aggregation, with compound IV being the most potent (22.3 and 17.0% inhibition at 100μM on Aβ42 and tau, resp.). Moreover, the most active compounds showed low cytotoxicity on a human brain cell line and they were predicted as BBB-permeable. In the experimental materials used by the author, we found tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Safety of tert-Butyl (5-aminopentyl)carbamate)
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Safety of tert-Butyl (5-aminopentyl)carbamate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics