Zhang, Shuguang; Tan, Xin; Liang, Chaogen; Zhang, Weihua published their research in Journal of Heterocyclic Chemistry in 2021. The article was titled 《Design, synthesis, and antifungal evaluation of novel coumarin-pyrrole hybrids》.Recommanded Product: 609-14-3 The article contains the following contents:
A series of coumarin derivatives I [R1 = H, CH3, CH2CH3, Cl; R2 = H, CH3, CF3, CH2Cl, (CH2)2CH3; R3 = H, CH3, OH; R4 = H, CH3; R5 = H, CH3; R1R2 = -(CH2)3-] bearing a pyrrole scaffold was designed, prepared, and assessed for their in vitro antifungal activities against six phytopathogenic fungi. The antifungal activity screening results suggest that some synthesized hybrids exhibited potential fungicidal activities against the tested fungi. In particular, compounds I (R1 = R5 = H, R2 = CH3, R3 = OH, R4 = CH3; R1 = R5 = H, R2 = (CH2)2CH3, R3 = OH, R4 = CH3; R1 = R4 = H, R2 = R3 = R5 = CH3; R1 = R4 = H, R3 = R5 = CH3, R2 = CF3; R1 = R4 = H, R3 = R5 = CH3, R2 = (CH2)2CH3) displayed significant antifungal effects against Rhizoctonia solani, and possessed EC50 values of 3.94, 7.75, 6.38, 6.25, and 7.67μg/ mL, resp. The above activities are more potent than the commercialized fungicide Boscalid (11.52μg/mL) and Osthole (9.79μg/mL). These results provide a significant reference for further rational design of coumarin-based fungicides. The experimental process involved the reaction of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Recommanded Product: 609-14-3)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: 609-14-3
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