Zacharioudakis, Emmanouil; Agianian, Bogos; Kumar MV, Vasantha; Biris, Nikolaos; Garner, Thomas P.; Rabinovich-Nikitin, Inna; Ouchida, Amanda T.; Margulets, Victoria; Nordstroem, Lars Ulrik; Riley, Joel S.; Dolgalev, Igor; Chen, Yun; Wittig, Andre J. H.; Pekson, Ryan; Mathew, Chris; Wei, Peter; Tsirigos, Aristotelis; Tait, Stephen W. G.; Kirshenbaum, Lorrie A.; Kitsis, Richard N.; Gavathiotis, Evripidis published the artcile< Modulating mitofusins to control mitochondrial function and signaling>, Quality Control of 112-63-0, the main research area is peptide mitofusin signaling mitochondrial function oligomerization.
Mitofusins reside on the outer mitochondrial membrane and regulate mitochondrial fusion, a physiol. process that impacts diverse cellular processes. Mitofusins are activated by conformational changes and subsequently oligomerize to enable mitochondrial fusion. Here, we identify small mols. that directly increase or inhibit mitofusins activity by modulating mitofusin conformations and oligomerization. We use these small mols. to better understand the role of mitofusins activity in mitochondrial fusion, function, and signaling. We find that mitofusin activation increases, whereas mitofusin inhibition decreases mitochondrial fusion and functionality. Remarkably, mitofusin inhibition also induces minority mitochondrial outer membrane permeabilization followed by sub-lethal caspase-3/7 activation, which in turn induces DNA damage and upregulates DNA damage response genes. In this context, apoptotic death induced by a second mitochondria-derived activator of caspases (SMAC) mimetic is potentiated by mitofusin inhibition. These data provide mechanistic insights into the function and regulation of mitofusins as well as small mols. to pharmacol. target mitofusins.
Nature Communications published new progress about Apoptosis-regulating protein DIABLO Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics