Yasui, Shinro; Itoh, Kenji; Ohno, Atsuyoshi published the artcile< Kinetic study on debromination of vic-dibromides with trivalent phosphorus compounds>, Application In Synthesis of 112-63-0, the main research area is vic dibromide debromination trivalent phosphorus kinetics; substituent effect vic dibromide debromination trivalent phosphorus.
Various types of trivalent phosphorus compounds PZ3 (PZ3 = P(2,6-OMe-C6H3)3, PPh3, PPh2OEt, PPh2OMe, PPh(OEt)2, PPh(OMe)2, P(OEt)3) brought about reductive debromination of vic-dibromides BrC(H)(Ph)-C(H)(R’)Br (R’ = Ph, COOEt, 4-NO2-C6H4) to afford olefins. The reaction was accelerated by either electron-releasing substituents on the phosphorus or electron-withdrawing substituents on the α-carbon of the vic-dibromides. The substituent effects, along with the stereochem. of the reaction, are consistent with an E1CB-like mechanism for the elimination of the two bromine atoms. That is, the phosphorus compounds initially undergo nucleophilic attack upon a bromine of the vic-dibromides. At the transition state, a fractional pos. charge is developed on the phosphorus and a fractional neg. charge on the carbon of the vic-dibromide. This mechanism suggests the importance of an electronic character of the vic-dibromide in determining the relative ease of bromophilicity, carbophilicity, and basicity of the phosphorus of a trivalent phosphorus compound in a reaction with the dibromide.
Heteroatom Chemistry published new progress about Bromides Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics