Recommanded Product: Ethyl 3-oxopentanoateIn 2019 ,《Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Yan, Zhongzhong; Liu, Aiping; Ou, Yingcan; Li, Jianming; Yi, Haibo; Zhang, Ning; Liu, Minhua; Huang, Lu; Ren, Jianwei; Liu, Weidong; Hu, Aixi. The article conveys some information:
Diflumetorim is a member of pyrimidinamine fungicides that possess excellent antifungal activities. Nevertheless, as reported that the activity of diflumetorim to corn rust (Puccinia sorghi) was not ideal (EC50 = 53.26 mg/L). Herein, a series of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety were designed based on our previous study and the structural characteristics of diflumetorim, synthesized and bioassayed to discover novel fungicides with excellent antifungal activities. Among these compounds, I gave the optimal fungicidal activity, which resp. offers control effects with EC50 values of 0.93 mg/L against P. sorghi and 1.24 mg/L against E. graminis, significantly superior to com. fungicides diflumetorim, tebuconazole, and flusilazole. Cell cytotoxicity results suggested that compound I has lower toxicities than diflumetorim. Furthermore, DFT calculation indicated that the phenyl-thiazole/oxazole moiety plays an unarguable role in the improvement of activity, which will contribute to designing and developing more potent compounds in the future. In the experimental materials used by the author, we found Ethyl 3-oxopentanoate(cas: 4949-44-4Recommanded Product: Ethyl 3-oxopentanoate)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Recommanded Product: Ethyl 3-oxopentanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics