In 2006,Parkkari, Teija; Savinainen, Juha R.; Raitio, Katri H.; Saario, Susanna M.; Matilainen, Laura; Sirvioe, Tuomas; Laitinen, Jarmo T.; Nevalainen, Tapio; Niemi, Riku; Jaervinen, Tomi published 《Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide》.Bioorganic & Medicinal Chemistry published the findings.Recommanded Product: Methyl 3-hydroxypropanoate The information in the text is summarized as follows:
Retroanandamide (2f) and its 10 analogs (1a-e, 2a-e) were synthesized and evaluated for the cannabinoid receptor activation by a [35S]GTPγS binding assay using rat cerebellar membranes, and Chinese hamster ovary cell membranes expressing human CB2 receptors. The primary goal of the study was to develop cannabinoid receptor agonists having improved enzymic stability compared to endogenous N-arachidonoyl ethanolamide (AEA). Furthermore, by reversing the amide bond of AEA, the formation of arachidonic acid would be prevented. Finally, an effect of the carbonyl carbon position on the cannabinoid receptor activity was explored by synthesizing retroanandamide analogs having different chain lengths (1a-e, C19; 2a-f, C20). All the synthesized compounds, except one, behaved as partial agonists for the both cannabinoid receptors. In rat brain homogenate, the reversed amides possessed significantly higher stability against FAAH induced degradation than AEA. Therefore, the reversed amide analogs of AEA may serve as enzymically stable structural basis for the drug design based on the endogenous cannabinoids. In addition to this study using Methyl 3-hydroxypropanoate, there are many other studies that have used Methyl 3-hydroxypropanoate(cas: 6149-41-3Recommanded Product: Methyl 3-hydroxypropanoate) was used in this study.
Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Methyl 3-hydroxypropanoate
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