More, Swati S.; Vince, Robert published the artcile< Design, synthesis and biological evaluation of glutathione peptidomimetics as components of anti-Parkinson prodrugs>, Application of C12H24N2O4, the main research area is glutathione peptidomimetic synthesis antiParkinson prodrug uptake blood brain barrier; peptide drug design antiParkinson prodrug CNS plasma disulfide bond; glucitol doramine oxidation regioselective epoxide opening peptide coupling adamantine.
Plethoras of CNS-active drugs fail to effect their pharmacol. response due to their in vivo inability to cross the blood-brain barrier (BBB). The classical prodrug approach to overcome this frailty involves lipophilic derivatives of the polar drug, but we herein report a novel approach by which endogenous transporters at BBB are exploited for brain drug delivery. The crucial role played by glutathione in pathogenesis of Parkinson’s and the presence of its influx transporters at the basolateral membrane of BBB served as the basis for our anti-Parkinson prodrug design strategy. A metabolically stable analog [I, R1 = adamantamine or (II)] of glutathione is used as a carrier for delivery of dopamine and adamantamine. An account of successful syntheses of these prodrugs along with their transport characteristics and stability determination is discussed.
Journal of Medicinal Chemistry published new progress about Antiparkinsonian agents. 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, Application of C12H24N2O4.
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