Application of 623-47-2In 2019 ,《Three-Component Approach to Pyridine-Stabilized Ketenimines for the Synthesis of Diverse Heterocycles》 appeared in Journal of Organic Chemistry. The author of the article were Massaro, Nicholas P.; Chatterji, Aayushi; Sharma, Indrajeet. The article conveys some information:
Ketenimines are versatile synthetic intermediates capable of performing novel transformations in organic synthesis. They are normally generated in situ due to their inherent instability and high level of reactivity. Herein, we report pyridine-stabilized ketenimine zwitterionic salts, which are prepared through click chem. from readily accessible alkynes and sulfonyl azides. To demonstrate their synonymous reactivity to ketenimines, these salts have been utilized in a cascade sequence to access highly functionalized quinolines including the core structures of an antiprotozoal agent and the potent topoisomerase inhibitor Tas-103. In the experiment, the researchers used Ethyl propiolate(cas: 623-47-2Application of 623-47-2)
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Application of 623-47-2
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