《Metal-Free Direct C-H β-Carbonyl Alkylation of Heteroarenes with Cyclopropanols Mediated by K2S2O8》 was written by Liu, Qiang; Wang, Qiang; Xie, Guanqun; Fang, Zeyang; Ding, Shujiang; Wang, Xiaoxia. Name: Methyl 4-fluorobenzoate And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:
Direct C-H β-carbonyl alkylation of heteroarenes under metal-, acid- and photo-catalyst free conditions has been achieved. A wide scope of substrates, such as various substituted quinolines and isoquinolines, pyridines, pyridazine, benzo[d]thiazole and phenanthroline, underwent the β-carbonyl alkylation efficiently via K2S2O8-mediated ring-opening of cyclopropanols. The corresponding β-heteroarylated ketones were obtained in moderate to excellent yields and gram-scale experiments further demonstrated the practicality of this synthetic protocol. The readily available reagents, mild and environmentally benign conditions make the method extremely attractive. The reaction mechanism is also proposed. In the part of experimental materials, we found many familiar compounds, such as Methyl 4-fluorobenzoate(cas: 403-33-8Name: Methyl 4-fluorobenzoate)
Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Name: Methyl 4-fluorobenzoate
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