In 2004,Kristiansen, Marit; Andersen, Birgitte; Iversen, Lars Fogh; Westergaard, Niels published 《Identification, Synthesis, and Characterization of New Glycogen Phosphorylase Inhibitors Binding to the Allosteric AMP Site》.Journal of Medicinal Chemistry published the findings.Recommanded Product: 329-59-9 The information in the text is summarized as follows:
Inhibition of glycogen phosphorylase (GP) has attracted considerable attention during the last five to 10 yr as a means of treating the elevated hepatic glucose production seen in patients with type 2 diabetes. Several different GP inhibitors binding to various binding sites of the GP enzyme have been reported in the literature. In this paper, novel compounds I [R1 = H, Cl, O2N, MeO, MeCO, HO2C; R2 = H, Cl, Me; R3 = H, Me; R4 = H, F, Br, MeO2C, PhCONH, etc.] that have been identified as potent GP inhibitors are reported. Their synthesis, mode of binding to the allosteric AMP site as well as in vitro data on GP inhibition are shown. The most potent inhibitor was found to be I [R1 = O2N; R2 = R3 = H; R4 = 3-O2NC6H4CONH] with an IC50 value of 74 nM. This compound together with a closely related analog was further characterized by enzyme kinetics and in primary rat hepatocytes.Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: 329-59-9) was used in this study.
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: 329-59-9Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics