Kourakis, Stephanie; Timpani, Cara A.; de Haan, Judy B.; Gueven, Nuri; Fischer, Dirk; Rybalka, Emma published the artcile< Dimethyl fumarate and its esters: a drug with broad clinical utility?>, Quality Control of 112-63-0, the main research area is review dimethyl fumarate ester antioxidative antiinflammatory inflammation oxidative stress; Nrf2; clinical application; dimethyl fumarate; disease; fumaric acid esters; inflammation; oxidative stress.
A review. Fumaric acid esters (FAEs) are small mols. with anti-oxidative, anti-inflammatory and immune-modulating effects. Di-Me fumarate (DMF) is the best characterized FAE and is approved and registered for the treatment of psoriasis and Relapsing-Remitting Multiple Sclerosis (RRMS). Psoriasis and RRMS share an immune-mediated etiol., driven by severe inflammation and oxidative stress. DMF, as well as monomethyl fumarate and diroximel fumarate, are commonly prescribed first-line agents with favorable safety and efficacy profiles. The potential benefits of FAEs against other diseases that appear pathogenically different but share the pathologies of oxidative stress and inflammation are currently investigated.
Pharmaceuticals published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics