Product Details of 51857-17-1In 2021 ,《A PROTAC targets splicing factor 3B1》 appeared in Cell Chemical Biology. The author of the article were Gama-Brambila, Rodrigo A.; Chen, Jie; Zhou, Jun; Tascher, Georg; Muench, Christian; Cheng, Xinlai. The article conveys some information:
The proteolysis-targeting chimeras (PROTACs) are a new technol. to degrade target proteins. However, their clin. application is limited currently by lack of chem. binders to target proteins. For instance, it is still unknown whether splicing factor 3B subunit 1 (SF3B1) is targetable by PROTACs. We recently identified a 2-aminothiazole derivative (herein O4I2) as a promoter in the generation of human pluripotent stem cells. In this work, proteomic anal. on the biotinylated O4I2 revealed that O4I2 targeted SF3B1 and pos. regulated RNA splicing. Fusing thalidomide-the ligand of the cereblon ubiquitin ligase-to O4I2 led to a new PROTAC-O4I2, which selectively degraded SF3B1 and induced cellular apoptosis in a CRBN-dependent manner. In a Drosophila intestinal tumor model, PROTAC-O4I2 increased survival by interference with the maintenance and proliferation of stem cell. Thus, our finding demonstrates that SF3B1 is PROTACable by utilizing noninhibitory chems., which expands the list of PROTAC target proteins. The experimental process involved the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Product Details of 51857-17-1)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Product Details of 51857-17-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics