Follmann, Markus’s team published research in Journal of Medicinal Chemistry in 2017 | CAS: 16982-21-1

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Application of 16982-21-1

In 2017,Follmann, Markus; Ackerstaff, Jens; Redlich, Gorden; Wunder, Frank; Lang, Dieter; Kern, Armin; Fey, Peter; Griebenow, Nils; Kroh, Walter; Becker-Pelster, Eva-Maria; Kretschmer, Axel; Geiss, Volker; Li, Volkhart; Straub, Alexander; Mittendorf, Joachim; Jautelat, Rolf; Schirok, Hartmut; Schlemmer, Karl-Heinz; Lustig, Klemens; Gerisch, Michael; Knorr, Andreas; Tinel, Hanna; Mondritzki, Thomas; Truebel, Hubert; Sandner, Peter; Stasch, Johannes-Peter published 《Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure》.Journal of Medicinal Chemistry published the findings.Application of 16982-21-1 The information in the text is summarized as follows:

The first-in-class soluble guanylate cyclase (sGC) stimulator riociguat was recently introduced as a novel treatment option for pulmonary hypertension. Despite its outstanding pharmacol. profile, application of riociguat in other cardiovascular indications is limited by its short half-life, necessitating a three times daily dosing regimen. In our efforts to further optimize the compound class, we have uncovered interesting structure-activity relationships and were able to decrease oxidative metabolism significantly. These studies resulting in the discovery of once daily sGC stimulator vericiguat (compound 24, BAY 1021189), currently in phase 3 trials for chronic heart failure, are now reported. In the experimental materials used by the author, we found Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Application of 16982-21-1)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Application of 16982-21-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics