In 2022,Ding, Lu; Song, Hao; Zheng, Chao; You, Shu-Li published an article in Journal of the American Chemical Society. The title of the article was 《Enantioselective Synthesis of Medium-Sized-Ring Lactones via Iridium-Catalyzed Z-Retentive Asymmetric Allylic Substitution Reaction》.Safety of Ethyl 2-methyl-3-oxobutanoate The author mentioned the following in the article:
An enantioselective synthesis of medium-sized-ring lactones, e.g., I, by iridium-catalyzed Z-retentive asym. allylic substitution reaction was reported. The reaction features mild conditions and a broad substrate scope. Various eight- to 11-membered-ring lactones can be afforded in moderate to excellent yields (up to 88%) and excellent enantioselectivity (up to 99% ee). The utilization of both Z-allyl precursors and Ir catalyst is critical for the medium-sized ring formation. The experimental process involved the reaction of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Safety of Ethyl 2-methyl-3-oxobutanoate)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Safety of Ethyl 2-methyl-3-oxobutanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics