In 2012,Barve, Indrajeet J.; Chen, Chan-Yu; Salunke, Deepak B.; Chung, Wen-Sheng; Sun, Chung-Ming published 《Design and Synthesis of New Biprivileged Molecular Scaffolds: Indolo-Fused Benzodiazepinyl/quinoxalinyl benzimidazoles》.Chemistry – An Asian Journal published the findings.Safety of Methyl 4-fluoro-3-nitrobenzoate The information in the text is summarized as follows:
The design and synthesis of new biprivileged mol. scaffolds with diverse structural features is reported. Com. available, simple heterocyclic building blocks such as 4-fluoro-3-nitrobenzoic acid, 2-chloro-3-nitrobenzoic acid, and indoline were utilized for the synthesis of the novel heterocycles. Pictet-Spengler-type condensation was used as a key step to construct tetracyclic indolobenzodiazepines and indoloquinoxalines linked with substituted benzimidazoles. Anal. of single crystals of representative compounds showed that these mol. skeletons have the potential to present various substituents with distinct three-dimensional orientations. The experimental process involved the reaction of Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Safety of Methyl 4-fluoro-3-nitrobenzoate)
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Safety of Methyl 4-fluoro-3-nitrobenzoateMethyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics