Barboza, Amanda A.; Neto, Attilio Chiavegatti; Rosset, Isac G.; Jardim, Guilherme A. M.; Ferreira, Marco A. B. published an article in 2021. The article was titled 《Synthesis of 3-Carbonyl Trisubstituted Furans via Pd-Catalyzed Aerobic Cycloisomerization Reaction: Development and Mechanistic Studies》, and you may find the article in Journal of Organic Chemistry.Recommanded Product: Ethyl 3-oxopentanoate The information in the text is summarized as follows:
Herein, synthesis of 3-carbonyl-trisubstituted furans via Pd-catalyzed oxidative cycloisomerization reactions of 2-alkenyl-1,3-dicarbonyl scaffolds, using mol. oxygen as the sole oxidant to regenerate active palladium catalytic species, featuring good functional tolerance and mild reaction conditions was reported. Deep investigation of intermediates and transition states of the reaction mechanism were conducted via exptl. and DFT studies, providing a detailed mechanistical profile. The new developed methodol. presents a greener alternative to Wacker-type cycloisomerizations and avoids the use of stoichiometric amounts of oxidants and strong acid additives. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Recommanded Product: Ethyl 3-oxopentanoate)
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Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics