《Synthesis and biological evaluation of panaxatriol derivatives against myocardial ischemia/reperfusion injury in the rat》 was written by Wu, Qiong; Wang, Ruiying; Shi, Yang; Li, Wenchao; Li, Meng; Chen, Peng; Pan, Bowen; Wang, Qing; Li, Caifeng; Wang, Jianbing; Sun, Guibo; Sun, Xiaobo; Fu, Hongzheng. Safety of Ethyl 2-amino-2-thioxoacetate And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:
Panaxatriol (PT) is a natural product derived from ginseng that possesses cardioprotective effects in isolated rat hearts. To develop more potent therapeutic agents against myocardial ischemia/reperfusion (MI/R) injury from natural products, a novel series of heterocycle ring-fused panaxatriol derivatives were designed and synthesized. In vitro results showed that approx. half of them exhibited increased cytoprotective activity compared with PT in a cardiomyocyte model of oxygen-glucose deprivation and reperfusion (OGD/R) injury. Furthermore, the in vitro activity of the representative derivative, isoxazole derivative I, was also confirmed in a rat model of MI/R injury. In vivo results showed that I can markedly reduce myocardial infarction size, decrease circulating cardiac troponin I (cTnI) leakage, and alleviate cardiac tissue damage in the rats. Therefore, these findings provide the basis for further development of novel anti-MI/R injury agents. In addition to this study using Ethyl 2-amino-2-thioxoacetate, there are many other studies that have used Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Safety of Ethyl 2-amino-2-thioxoacetate) was used in this study.
Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Safety of Ethyl 2-amino-2-thioxoacetate
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