《Rapid access to 3-acyl indoles using ethyl acetate/triflic acid couple as the acylium donor and Cu(OAc)2 catalysed aerial oxidation of indole benzoins》 was written by Talukdar, Ranadeep. Reference of Methyl 4-fluorobenzoate And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:
A facile installation of acyl groups at the C-3 position of indoles under triflic acid catalyzed conditions with easily available and cheap esters as new acylating agents was described. Furthermore, heterocycles like N-protected pyrrole, furan and thiophene were also suitable substrates for similar C-2 acylation. Analogous C-3 benzoylated products of indole were obtained, albeit in lower yields, by using Me benzoate as a benzoyl donor. The benzoylated products were synthesized in much better yields via a copper(II) catalyzed aerial oxidation of indole containing benzoins. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Reference of Methyl 4-fluorobenzoate)
Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Reference of Methyl 4-fluorobenzoate
Referemce:
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