The author of 《Aziridine electrophiles in the functionalization of peptide chains with amine nucleophiles》 were Spork, Anatol P.; Donohoe, Timothy J.. And the article was published in Organic & Biomolecular Chemistry in 2015. Synthetic Route of C8H17NO2 The author mentioned the following in the article:
We describe herein the synthesis of aziridine-containing amino acids embedded within tripeptide structures. A range of amine nucleophiles have been shown to open the aziridine amino acid regioselectively at the β-position under mild conditions and without the requirement for a catalyst, forming new adducts in the process. Amino acid N-termini (or an N-containing side-chain) also served as effective nucleophiles for such aziridines and this concept could be extended to encompass a di- or tripeptide nitrogen as a nucleophile, thus providing new methodol. for linking together peptide strands using an amine linker. In the experiment, the researchers used many compounds, for example, Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2Synthetic Route of C8H17NO2)
Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Synthetic Route of C8H17NO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics