The author of 《Triazole-based inhibitors of the Wnt/β-catenin signaling pathway improve glucose and lipid metabolisms in diet-induced obese mice》 were Obianom, Obinna N.; Ai, Yong; Li, Yingjun; Yang, Wei; Guo, Dong; Yang, Hong; Sakamuru, Srilatha; Xia, Menghang; Xue, Fengtian; Shu, Yan. And the article was published in Journal of Medicinal Chemistry in 2019. HPLC of Formula: 4949-44-4 The author mentioned the following in the article:
Wnt/β-catenin signaling pathway is implicated in the etiol. and progression of metabolic disorders. Although lines of genetic evidence suggest that blockage of this pathway yields favorable outcomes in treating such ailments, few inhibitors have been used to validate the promising genetic findings. Here, we synthesized and characterized a novel class of triazole-based Wnt/β-catenin signaling inhibitors and assessed their effects on energy metabolism One of the top inhibitors, I, promoted Axin stabilization, which led to the proteasome degradation of β-catenin and subsequent inhibition of the Wnt/β-catenin signaling in cells. Treatment of hepatocytes and high fat diet-fed mice with I resulted in significantly decreased hepatic lipid accumulation. Moreover, I improved glucose tolerance of high fat diet-fed mice without noticeable toxicity, while downregulating the genes involved in the glucose and fatty acid anabolisms. The new inhibitors are expected to be further developed for the treatment of metabolic disorders. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxopentanoate(cas: 4949-44-4HPLC of Formula: 4949-44-4)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.HPLC of Formula: 4949-44-4
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