Recommanded Product: N-Boc-1,6-DiaminohexaneIn 2021 ,《Discovery of sertraline and its derivatives able to combat drug-resistant gastric cancer cell via inducing apoptosis》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Mu, Chao; Peng, Rui-Kun; Guo, Chun-Ling; Li, Ao; Yang, Xiu-Ming; Zeng, Rong; Li, Yu-Long; Gu, Jing; Ouyang, Qin. The article contains the following contents:
Resistance phenomena during chemotherapy of tumor has been severely hampering the applications of chemotherapeutics. Due to advantage of drug repurposing, discovery of new chemosensitizers based on approved drugs is an effect strategy to find new candidates. Herein, we found antidepressant drug – sertraline, could sensitize drug-resistant gastric cancer cell (SGC-7901/DDP) with the IC50 value of 18.73μM. To understand the structure-activity relationship and improve the activity, 30 derivatives were synthesized and evaluated. The IC50 value of the best compound was improved to 5.2μM. Moreover, we found apoptosis induction and cell cycle arrest was the reason for the cell death of the drug-resistant cells after treatment of sertraline and derivatives, and PI3K/Akt/mTOR pathway was involved. The experimental process involved the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Recommanded Product: N-Boc-1,6-Diaminohexane)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Recommanded Product: N-Boc-1,6-Diaminohexane
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