Kervefors, Gabriella; Kersting, Leonard; Olofsson, Berit published their research in Chemistry – A European Journal in 2021. The article was titled 《Transition metal-free N-arylation of amino acid esters with diaryliodonium salts》.Synthetic Route of C12H15ClN2O2 The article contains the following contents:
A transition metal-free approach for the N-arylation of amino acid derivatives has been developed. Key to this method is the use of unsym. diaryliodonium salts with anisyl ligands, which proved important to obtain high chemoselectivity and yields. The scope includes the transfer of both electron deficient, electron rich and sterically hindered aryl groups with a variety of different functional groups. Furthermore, a cyclic diaryliodonium salt was successfully employed in the arylation. The N-arylated products were obtained with retained enantiomeric excess. In addition to this study using H-Trp-OMe.HCl, there are many other studies that have used H-Trp-OMe.HCl(cas: 7524-52-9Synthetic Route of C12H15ClN2O2) was used in this study.
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Synthetic Route of C12H15ClN2O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics