On December 1, 2013, Eibl, Christoph; Munoz, Lenka; Tomassoli, Isabelle; Stokes, Clare; Papke, Roger L.; Guendisch, Daniela published an article.Computed Properties of 227940-70-7 The title of the article was The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: Carboxamide derivatives with different spacer motifs. And the article contained the following:
3,7-Diazabicyclo[3.3.1]nonane (bispidine) based nicotinic acetylcholine receptor (nAChR) ligands, e.g., I, have been synthesized and evaluated for nAChRs interaction. Diverse spacer motifs were incorporated between the hydrogen bond acceptor (HBA) part and a variety of substituted (hetero)aryl moieties. Bispidine carboxamides bearing spacer motifs often showed high affinity in the low nanomolar range and selectivity for the α4β2* nAChR. Compound I and the other two tested compounds with Ki values of about 1 nM displayed the highest affinities for α4β2* nAChR. All evaluated compounds are partial agonists or antagonists at α4β2*, with reduced or no effects on α3β4* with the exception of compound I (agonist), and reduced or no effect at α7 and muscle subtypes. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Computed Properties of 227940-70-7
The Article related to brain disease, central nervous system agents, central nervous system disease, laburnum anagyroides (seeds and pods), mathematical methods (acd/adme and acd/physchem), nicotinic agonists, nicotinic antagonists, structure-activity relationship and other aspects.Computed Properties of 227940-70-7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics