《Probing the B- & C-rings of the antimalarial tetrahydro-β-carboline MMV008138 for steric and conformational constraints》 was written by Ding, Sha; Ghavami, Maryam; Butler, Joshua H.; Merino, Emilio F.; Slebodnick, Carla; Cassera, Maria B.; Carlier, Paul R.. SDS of cas: 7524-52-9 And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:
The antimalarial candidate MMV008138 (1a, I, (1R,3S) active isomer shown) is of particular interest because its target enzyme (IspD) is absent in human. To achieve higher potency, and to probe for steric demand, a series of analogs of 1a were prepared that featured methyl-substitution of the B- and C-rings, as well as ring-chain transformations. X-ray crystallog., NMR spectroscopy and calculation were used to study the effects of these modifications on the conformation of the C-ring and orientation of the D-ring. Unfortunately, all the B- and C-ring analogs explored lost in vitro antimalarial activity. The possible role of steric effects and conformational changes on target engagement are discussed. The experimental part of the paper was very detailed, including the reaction process of H-Trp-OMe.HCl(cas: 7524-52-9SDS of cas: 7524-52-9)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.SDS of cas: 7524-52-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics