The author of 《Ketamine esters and amides as short-acting anesthetics: structure-activity relationships for the side-chain》 were Dimitrov, Ivaylo V.; Harvey, Martyn G.; Voss, Logan J.; Sleigh, James W.; Bickerdike, Michael J.; Denny, William A.. And the article was published in Bioorganic & Medicinal Chemistry in 2019. Name: Diethyl 2-methylmalonate The author mentioned the following in the article:
N-Aliphatic ester analogs of the non-opioid ketamine (1) retain effective anesthetic/analgesic properties while minimizing ketamine’s psychomimetic side-effects. We show that the anesthetic/analgesic properties of these ester analogs depend critically on the length (from 2 to 4 carbons), polarity and steric cross-section of the aliphatic linker chain. More stable amide and ethylsulfone analogs generally showed weaker anesthetic/analgesic activity. There was no correlation between the anesthetic/analgesic properties of the compounds and their binding affinities for the N-methyl-D-aspartate (NMDA) receptor.Diethyl 2-methylmalonate(cas: 609-08-5Name: Diethyl 2-methylmalonate) was used in this study.
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Name: Diethyl 2-methylmalonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics