《Synthesis and antimalarial activity of (S)-methyl-(7-chloroquinolin-4-ylthio)acetamidoalquilate derivatives》 was written by Colmenarez, Custodiana; Acosta, Maria; Rodriguez, Miguel; Charris, Jaime. Related Products of 7524-52-9 And the article was included in Journal of Chemical Research in 2020. The article conveys some information:
The synthesis of five new (S)-methyl-(7-chloroquinolin-4-ylthio)acetamidoalquilate derivatives I (R = Me, propan-2-yl, 2-methylpropyl, benzyl,1H-indol-3-ylmethyl) is carried out under a modified version of the Steglich esterification reaction between different L-amino acid Me esters (S)-H2NCH(R)C(O)OCH3.HCl and 2-(7-chloroquinolin-4-ylthio)acetic acid. Two of the compounds showed significant inhibition (>50%) of β-hematin formation. The two active structures were tested in vivo as potential antimalarials in mice infected with Plasmodium berghei ANKA, a chloroquine susceptible strain. Compounds I (R = propan-2-yl, 1H-indol-3-ylmethyl) exhibited antimalarial activity comparable to that of chloroquine. The experimental process involved the reaction of H-Trp-OMe.HCl(cas: 7524-52-9Related Products of 7524-52-9)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Related Products of 7524-52-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics