《Design, synthesis, and biological evaluation of novel 4H-chromen-4-one derivatives as antituberculosis agents against multidrug-resistant tuberculosis》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Zhao, Wenting; Wang, Bin; Liu, Yuke; Fu, Lei; Sheng, Li; Zhao, Hongyi; Lu, Yu; Zhang, Dongfeng. SDS of cas: 403-33-8 The article mentions the following:
A series of 4H-chromen-4-one derivatives I (R1 = H, C6H5, 4-FC6H4, etc.; R2 = H, piperidin-1-ylmethyl, pyrrolidin-1-ylmethyl, etc.; R3 = H, 4-HOC6H4, Et formate, etc.) obtained by scaffold morphing of the benzofuran compound, TAM16, were tested for antitubercular activity. Compound I (R1 = 4-HOC6H4; R2 = azetidin-1-ylmethyl; R3 = H) was active against drug-sensitive and multidrug-resistant tuberculosis. A preliminary druggability evaluation showed that the above compound displayed favorable mouse and human microsomal stability, low cytotoxicity, and acceptable oral bioavailability. An in vivo study indicated that the above compound exhibited modest efficacy in an acute mouse model of TB after 3 wk of treatment. Thus, the above compound is a promising antituberculosis lead compound The experimental part of the paper was very detailed, including the reaction process of Methyl 4-fluorobenzoate(cas: 403-33-8SDS of cas: 403-33-8)
Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.SDS of cas: 403-33-8
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